GLP-1 / incretin
Semaglutide
Multiple large human RCTs
Approved (Ozempic / Wegovy).
What's actually proven
- ✓~15% average weight loss at 2.4 mg weekly over 68 weeks (STEP-1).
- ✓Reduced major cardiovascular events by 20% in people with obesity and heart disease (SELECT).
The bullshit / overstated
- ✗"You'll keep the weight off" — most people regain about two-thirds within a year of stopping.
- ✗Compounded/research versions are not the same product as Wegovy.
Side effects
- •Nausea, vomiting, diarrhoea, constipation
- •Gallstones
- •Muscle loss without resistance training
Don't use if
- !Medullary thyroid cancer / MEN2 history
- !Pancreatitis history
- !Pregnancy